Na+K+-ATPase-specific peptide inhibitors/activators of SRC and SRC family kinases
AssigneeThe University of Toledo
InventorsZijian Xie, Joseph I. Shapiro, Jiang Tian
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Abstract
A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific.
Claims6
A peptide comprising a helix or helix-like structure that binds to Src kinase domain, wherein the peptide is identified based on the helix structure of P3 consisting of SEQ ID NO:2.
A peptide comprising SEQ ID NO:49, which consists of SEQ ID NO:
- 47 conjugated to SEQ ID NO:
- 2.
A peptide comprising SEQ ID NO:50, which consists of SEQ ID NO:
- 48 conjugated to SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.