Compositions comprising modified collagen and uses therefor
AssigneeThe Johns Hopkins University
InventorsMichael Yu, Jennifer H. Elisseeff, Hyeseung Janice Lee, Xiao Mo, Allen Yi-Lan Wang
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Abstract
The invention provides modified collagen and related therapeutic and diagnostic methods.
Claims6
A method for modifying collagen, the method comprising contacting collagen with a collagen mimetic peptide consisting of Z-[X-Y-Gly]2-20 repeat unit (SEQ ID NO:1), wherein Z is any amino acid, X is proline or modified proline, Y is proline or modified proline, under conditions that provide for a physical interaction between the collagen and the collagen mimetic peptide.
A method for modifying collagen, the method comprising contacting collagen with a collagen mimetic peptide consisting of an amino acid sequence selected from the group consisting of:
- Gly3-(ProHypGly)6, (SEQ ID NO:13)
- Gly3-(ProHypGly)7, (SEQ ID NO:14)
- Gly3-(ProHypGly)8, (SEQ ID NO:15)
- Gly3-(ProHypGly)9, (SEQ ID NO:16)
- (ProHypGly)6-Tyr, (SEQ ID NO:17)
- (ProHypGly)7-Tyr, (SEQ ID NO:18)
- (ProHypGly)8-Tyr, (SEQ ID NO:19)
- Cys-(Pro-Hyp-Gly)3, (SEQ ID NO:20)
- Cys-(Pro-Hyp-Gly)5, (SEQ ID NO:21) and
- Cys-(Pro-Hyp-Gly)7 (SEQ ID NO:22) under conditions that provide for a physical interaction between the collagen and the collagen mimetic peptide.
Dependencies are inferred from the claim text.