Conjugated psychotropic drugs and uses thereof
AssigneesRamot at Tel-Aviv University Ltd., Bar-Ilan University
InventorsAbraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman
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Abstract
Novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and/or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses are disclosed. The organic acids are selected to reduce side effects induced by the psychotropic drugs and/or to exert an anti-proliferative activity.
Claims7
A method of synthesizing a chemical conjugate of nortriptyline and γ-aminobutyric acid, comprising:
- reacting the nortriptyline and the γ-aminobutyric acid, so as to obtain the chemical conjugate of the nortriptyline and the γ-aminobutyric acid, wherein the nortriptyline and the γ-aminobutyric acid are covalently linked via an amide bond.
A chemical conjugate comprising nortriptyline covalently linked to a butyric acid substituted with an amino group as shown below:
Dependencies are inferred from the claim text.