2, 6 xylidine derivatives for the treatment of pain
AssigneeKrisani Biosciences (P) Ltd
InventorMahesh Kandula
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Abstract
The disclosure herein provides a compound of formula 1. The disclosure also provides a method of synthesizing the compound of formula 1. The compound of formula 1 or its pharmaceutical acceptable salts, as well as polymorphs, solvates, and hydrates thereof may be formulated as pharmaceutical composition. The pharmaceutical composition of compound of formula 1 or the final compound may be formulated for non-invasive peroral, topical (example transdermal), enteral, transmucosal, targeted delivery, sustained release delivery, delayed release, pulsed release and parenteral methods. Such compositions may be used to treat chronic pain manifested with chronic diseases or its associated complications. The compound may also be offered as a kit.
Claims10
A compound, comprising of formula 1:
A method of treating pain, comprising:
- administering the compound of formula 1 as shown below to a patient suffering from a disease
- wherein the disease is at least one of a chronic disease, chronic disorder, hematological disease, inflammation, orthopedic disease, cardiovascular disease, renal disease, skin disease, neurological disease, metastasis disease and ocular complications.
A method of making the compound of formula 1, comprising:
- adding the solution of 2, 6 xylidine dissolved in dichloromethane and chloroacetyl chloride for 30 minutes at 0° C. to make a mixture;
- raising the temperature of the mixture and stirring it overnight for a reaction to obtain a reaction mixture;
- monitoring the completion of the reaction by thin layer chromatography;
- washing the reaction mixture with water followed by washing with brine solution;
- separating an organic and an inorganic layer from the reaction mixture;
- drying the organic layer over anhydrous Na2SO4 as a solid;
- evaporating the remaining liquid to get a dry solid;
- recrystallizing the dry solid using a hexane;
- and
- filtering a recrystallized dried material to yield a compound 2
A kit, comprising:
- a pharmaceutical composition of formula 1
- and an instruction for using the compound for treatment of pain.
Dependencies are inferred from the claim text.