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US 8,283,368 B2Granted
Selective ligands for the dopamine 3 (D3) receptor and methods of using the same
AssigneeThe Regents of the University of Michigan
InventorsShaomeng Wang, Jianyong Chen, Gregory Collins, James H. Woods, Beth Levant
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Abstract
Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula (I) wherein X is C═O or SO2, R1 is C1-6 alkyl, R2 is aryl, heteroaryl, aryl, —(CH2)1-3aryl, or —(CH2)1-3heteroaryl, and n is 0 or 1. Methods of using the D3 receptor ligands in the treatment of diseases and conditions wherein modulation of the D3 receptor provides a benefit also are disclosed.
Claims26
A compound having a structural formula
- wherein X is C═O or SO2, R1 is C1-6 alkyl, R2 is unsubstituted or substituted and is aryl, heteroaryl, —(CH2)1-3aryl, or —(CH2)1-3heteroaryl, and n is 0 or 1, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.