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US 8,283,365 B2Granted
Indole modulators of the alpha 7 nicotinic acetylcholine receptor
AssigneeProximagen Limited
InventorsKevin Dinnell, Andrew P Lightfoot, Howard Robert Marshall
Life of this patent
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Abstract
This invention relates to modulation of the α7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a salt thereof
Claims11
A compound of formula (I) or a salt thereof:
- wherein:
- R1 is hydrogen or C1-3alkyl;
- R2 is hydrogen, halo or cyano;
- and
- R3 is group
- wherein Ra is halo, C1-6alkyl, C1-6alkoxy, haloC1-6alkyl, haloC1-6alkoxy or cyano.
3 more elements
A compound which is:
- N-[(2-trifluoromethyl-1H-indol-5-yl)methyl]-6-(trifluoromethyl)-3-pyridinecarboxamide;
- N-[(2-trifluoromethyl-1H-indol-5-yl)methyl]-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide;
- 6-bromo-N-{[2-(trifluoromethyl)-1H-indol-5-yl]methyl}-3-pyridinecarboxamide;
- 6-cyano-N-{[2-(trifluoromethyl)-1H-indol-5-yl]methyl}-3-pyridinecarboxamide;
- N-[(2-trifluoromethyl-7-bromo-1H-indol-5-yl)methyl]-6-(trifluoromethyl)-3-pyridinecarboxamide;
- N-[(2-trifluoromethyl-7-cyano-1H-indol-5-yl)methyl]-6-(trifluoromethyl)-3-pyridinecarboxamide;
- N-[(1-methyl-2-trifluoromethylindol-5-yl)methyl]-6-(trifluoromethyl)-3-pyridinecarboxamide;
- or
- a salt thereof.
6 more elements
A compound which is N-[(2-Trifluoromethyl-1H-indol-5-yl)methyl]-6-(trifluoromethyl)-3-pyridinecarboxamide.
Dependencies are inferred from the claim text.