Cyclic and acyclic hydrazine derivatives compositions including them and uses thereof
AssigneeInstitute for OneWorld Health
InventorsMichael Geoffrey Neil Russell, Huw David Vater, Jacqueline Anne Macritchie, Kevin James Doyle, David Brown, Joanne Peach
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Abstract
The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of the functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a cyclic or acyclic hydrazine derivative including those of formulas II or III: or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
Claims5
A compound represented by formula II:
- wherein:
- R2 is substituted aryl, substituted with 1 or 2 halo groups;
- X and X1 are independently halo;
- is a single or double bond;
- and
- n is 1;
- or a pharmaceutically acceptable salt thereof.
A compound represented by formula III:
- wherein:
- R1 is substituted alkyl, substituted with an aryl group that is optionally substituted with a hydroxy group;
- X and X1 are independently halo;
- and
- is a single or double bond;
- or a pharmaceutically acceptable salt thereof.
A compound which is:
- 6-(3,5-dibromo-4-hydroxyphenyl)-2-(3-hydroxybenzyl)-4,5-dihydropyridazin-3(2H)-one or
- (3-bromo-4-chlorophenyl)(3-(3,5-dibromo-4-hydroxyphenyl)-4,5-dihydro-1 H-pyrazol-1-yl)methanone, or
- a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.