Vinyl phosphonate lysophosphatidic acid receptor antagonists

A compound having the formula

• wherein Z is —CY═CH— in the trans (e) configuration;
• Y is hydrogen or halogen,
• each R1 is independently halo, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, —NH2, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, or cyano;
• and
• R2 is hydrogen, halo, (C1-C12)alkyl, halo(C1-C12)alkyl, halo(C1-C12)alkoxyl, (C3-C10)cycloalkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, —NH2, —NH(C1-C12)alkyl, —N((C1-C12)alkyl)2, aryl, (C1-C12)alkaryl, aryl(C1-C12)alkyl, or aryl-substituted aryl(C1-C12)alkyl;
• each R3 is independently halo, (C1-C12)alkyl, halo(C1-C12)alkyl, halo(C1-C12)alkoxyl, (C3-C10)cycloalkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, —NH2, —NH(C1-C12) alkyl, —N((C1-C12)alkyl)2, aryl, (C1-C12)alkaryl, aryl(C1-C12)alkyl, or aryl-substituted aryl(C1-C12)alkyl;
• R4 is (C6-C24)alkyl, halo(C6-C24)alkyl, (C6-C24)alkoxy, —NH2, —NH(C1-C24)alkyl, —N((C1-C24)alkyl)2, cyano, (C3-C10)cycloalkyl, (C4-C15)bicycloalkyl, (C6-C24)alkenyl, (C6-C24)alkenyl, (C6-C24)-alkynyl, aryl, (C6-C24)alkaryl, aryl(C6-C24)alkyl, or aryl-substituted aryl(C6-C24)alkyl;
• wherein the alkyl, alkenyl aryl groups of R4 can be optionally substituted with halo, alkoxy or cyano;
• or
• R5 and R6 are independently hydroxy, (C1-C12)alkyl-O—, (C2-C12)alkenyl-O—, (C2-C12)alkynyl-O—, (C6-C10)aryl-O—,
• m is 0, 1, 2, 3, or 4;
• n is 0, 1, 2, or 3;
• or a pharmaceutically acceptable salt or ester thereof.