PFKFB4 inhibitors and methods of using the same
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorsSucheta Telang, Jason Chesney
Life of this patent
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Abstract
Methods of reducing expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) and methods of treating a cancer in a cell are provided, the methods including contacting a cell with an effective amount of a PFKFB4 inhibitor. Short hairpin RNA (shRNA) and small interfering RNA (siRNA) inhibitors of PFKFB4 and their methods of use are also provided.
Claims13
A method of reducing expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4), comprising contacting a cell with an effective amount of a PFKFB4 inhibitor, wherein the PFKFB4 inhibitor is a small interfering RNA (siRNA) having a first nucleic acid sequence and a second nucleic acid sequence, wherein said first nucleic acid sequence consists of a nucleic acid sequence selected from the group consisting of SEQ ID NO:
- 8 and SEQ ID NO:
- 9.
A method of treating a cancer cell, comprising contacting the cell with an effective amount of a PFKFB4 inhibitor, wherein the PFKFB4 inhibitor is a small interfering RNA (siRNA) having a first nucleic acid sequence and a second nucleic acid sequence, wherein said first nucleic acid sequence consists of a nucleic acid sequence selected from the group consisting of SEQ ID NO:
- 8 and SEQ ID NO:
- 9.
A method of reducing expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4), comprising contacting a cell with an effective amount of a PFKFB4 inhibitor, wherein the PFKFB4 inhibitor is a small hairpin RNA (shRNA) comprising a nucleic acid sequence that is SEQ ID NO:
- 4 or SEQ ID NO:
- 5.
A method of treating a cancer cell, comprising contacting the cell with an effective amount of a PFKFB4 inhibitor, wherein the PFKFB4 inhibitor is a small hairpin RNA (shRNA) comprising a nucleic acid sequence that is SEQ ID NO:
- 4 or SEQ ID NO:
- 5.
Dependencies are inferred from the claim text.