Immunomodulatory and anti-tumour peptides
AssigneeCentro de Ingenieria Genetica y Biotecnologia
InventorsMaribel Guerra Vallespi, Isis del Carmen Torréns Madrazo, Osvaldo Reyes Acosta, Hilda Elisa Garay Pérez, Gerardo Enrique Guillén Nieto, Boris Ernesto Acevedo Castro, Raimundo Ubieta Gómez
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Abstract
The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKYKGKFW (SEQ ID NO.: 13), showing amino acid substitutions, these peptides unable to bind to the lipopolysaccharides and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.
Claims18
A synthetic peptide comprising a peptide selected from the group consisting of SEQ ID NO:
- 1;
- SEQ ID NO:
- 2;
- SEQ ID NO:
- 3;
- and SEQ ID NO:
- 4.
A synthetic peptide consisting of a peptide selected from the group consisting of SEQ ID NO:
- 1;
- SEQ ID NO:
- 2;
- SEQ ID NO:
- 3;
- and SEQ ID NO:
- 4.
A method for treating cancer comprising administering an effective amount of a synthetic peptide comprising a peptide selected from the group consisting of SEQ ID NO:
- 1;
- SEQ ID NO:
- 2;
- SEQ ID NO:
- 3, and SEQ ID NO:
- 4 to an animal or a human.
A method for treating cancer comprising administering an effective amount of a synthetic peptide consisting of a peptide selected from the group consisting of SEQ ID NO:
- 1;
- SEQ ID NO:
- 2;
- SEQ ID NO:
- 3, and SEQ ID NO:
- 4 to an animal or a human.
Dependencies are inferred from the claim text.