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US 8,283,317 B1Granted
Nanoparticles for protein drug delivery
AssigneesGP Medical, Inc., National Tsing Hua University
InventorsHsing-Wen Sung, Zi-Xian Liao, Shu-Fen Peng, Hosheng Tu
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Abstract
The invention discloses particulate complexes composed of chitosan, poly-glutamic acid, and at least one bioactive agent, wherein equal moles of the positively charged chitosan and the negatively charged poly-glutamic acid substrate form an electrostatic network enabling improved loading the bioactive agent.
Claims20
A method of delivering at least one bioactive agent to an animal subject with enhanced cellular uptake of said at least one bioactive agent by said subject, the method comprising:
- (a) loading said bioactive agent in particulate complexes, wherein the particulate complexes comprise a core portion of positively charged chitosan, an outer portion of a negatively charged substrate, optionally a zero-charge compound, and said bioactive agent loaded in the core portion, wherein said particulate complexes have a mean complex size between about 50 and 400 nanometers;
- and (b) delivering said particulate complexes via a parenteral route to said animal subject.
Dependencies are inferred from the claim text.