Compositions and methods for modulating body weight and treating obesity-related disorders
AssigneeThe Research Foundation of State University of New York
InventorsMichael M. Meguid, Susumu Suzuki
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Abstract
The present invention relates to compositions and methods for regulating body weight, and for treating conditions associated with obesity, particularly, obesity-related diabetes. The present invention is premised on the discovery that body weight can be effectively regulated by modulating the levels and/or activities of two gut hormones, PYY and ghrelin.
Claims10
A pharmaceutical composition for reducing body weight or rate of weight gain, comprising an effective amount of a combination of (a) one or more of PYY, a peptide consisting of amino acid 3 to 36 of a human PYY, PYY3-36, PYY22-36, BIM-43004, BIM-43073D, BIM-43004C, N-α-Ac-[Phe27]PYY(22-36), N-α-Ac-[TRP27]PYY(22-36), N-α-Ac-[Thi27]PYY(22-36), N-α-Ac-[Tyr22, Phe27]PYY(22-36), [Im-DNP-His26]PYY, PYY(22-36), [Ala32]PYY(22-36), [Ala23,32]PYY(22-36), [Glu28]PYY(22-36), N-α-Ac-PYY(22-36), N-α-Ac-[p.Cl-Phe27]PYY(22-36), N-α-Ac-[Glu26]PYY(22-36), N-α-Ac-[N-Me-Tyr36]PYY(22-36), N-α-Myristoyl-PYY(22-36), N-α-Naphthaleneacetyl-PYY(22-36), N-α-Ac-[Phe27]PYY(22-36), N-α-Ac-[Bth27]PYY(22-36), N-α-Ac-[Bip27]PYY(22-36), N-α-Ac-[Nal27]PYY(22-36), N-α-Ac-[Tic27]PYY(22-36), N-α-Ac-[Phe27]PYY(25-36), N-α-Ac-[Trp27]PYY(22-36), PYY(13-36), NPY(13-36), and (b) a ghrelin.
A pharmaceutical composition for increasing the body weight or decreasing the rate of weight loss in a subject, comprising an effective amount of a combination of an antagonist of PYY or PYY receptor with a ghrelin.
Dependencies are inferred from the claim text.