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US 8,283,162 B2Granted
Antibodies relating to PIVKAII and uses thereof
AssigneeAbbott Laboratories
InventorsToru Yoshimura, Barry L. Dowell, Gangamani S. Beligere, Qiaoqiao Ruan
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Abstract
The present invention relates to antibodies that may be used, for example, in the diagnosis, treatment and prevention of haepatocellular carcinoma (HCC), liver cancer and related conditions.
Claims10
A hybridoma cell line designated by American Type Culture Collection (ATCC) deposit designation PTA-9638.
A method of producing a hybridoma cell line which expresses a binding protein comprising an antigen-binding domain which binds to amino acids 13-27 of PIVKA-II comprising the steps of:
- a) immunizing a GANP mouse with an antigen comprising amino acids 13-27 of PIVKA-II for a time and under conditions sufficient for said mouse to produce antibodies against said antigen;
- b) harvesting and purifying B cells from the spleen of said mouse;
- c) fusing said spleen cells with myeloma cells in order to produce hybridomas;
- and
- d) selecting a hybridoma cell line which expresses said binding protein comprising an antigen-binding domain which binds to amino acids 13-27 of PIVKA-II, wherein said hybridoma cell line has ATCC deposit designation PTA-9638.
2 more elements
Dependencies are inferred from the claim text.