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AssigneeCj Cheiljedang Corporation
InventorsSo Young Kim, Yong Uk Shin, In Kyung Heo, Hyun Ah Kim, Chang Il Seo, Ju Eun Kim, Sung Kwang Son, Sang Mok Lee, Sung Hoo Jhon, Han Jin Lee, Kwang Ho Na
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Disclosed is a strain of Escherichia sp., capable of producing O-acetyl homoserine in high yield, with the introduction and enhancement therein of the activity of: homoserine acetyl transferase, aspartokinase and homoserine dehydrogenase; and at least one enzyme selected from a group consisting of phosphoenolpyruvate carboxylase, aspartate aminotransferase and aspartate semi-aldehyde dehydrogenase. Also, a method of producing O-acetyl homoserine using the strain is provided.
A strain of Escherichia coli, capable of producing O-acetyl homoserine in high yield, which overexpresses homoserine acetyl transferase, aspartokinase, homoserine dehydrogenase, phosphoenolpyruvate carboxylase, aspartate aminotransferase, and aspartate semi-aldehyde dehydrogenase, wherein aspartokinase and homoserine dehydrogenase, phosphoenolpyruvate carboxylase, aspartate aminotransferase, aspartate semi-aldehyde dehydrogenase, and homoserine acetyl transferase are encoded by respective genes thrA, ppc, aspC and asd from Escherichia coli and metX from Deinococcus radiodurans.
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