Oral care compositions containing combinations of anti-bacterial and host-response modulating agents

A topical oral composition comprising in an orally-acceptable carrier a combination of

• (a) from about 0.001% to about 10% by weight of the composition of two or more of anti-inflammatory agents having inhibitory activity against two or more of host pro-inflammatory factors selected from matrix metalloproteinases (MMP's), cyclooxygenases (COX), PGE2, interleukin 1 (IL-1), or nuclear factor kappa B (NF-κB) and
• (b) from about 0.01% to about 20% by weight of the composition of one or more of an antibacterial agent having inhibitory activity against one or more bacterial species selected from Porphyromonas gingivalis, Bacteroides forsythus or Actinobacillus actinomycetemcomitans and bacterial virulence factors selected from biofilm formation or biofilm adherence,
• wherein the combination is present in an amount effective to provide enhanced efficacy to treat and prevent bacteria-mediated oral cavity conditions, with the proviso that the composition does not comprise other anti-inflammatory agents selected from aspirin, ibuprofen, flurbiprofen or indomethacin.