Methods and compositions for monitoring and risk prediction in cardiorenal syndrome
AssigneeAlere San Diego, Inc.
InventorsGunars Valkirs, Paul H. McPherson
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Abstract
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to monitor cardiorenal syndrome using assays that detect NGAL, preferably together with assays that detect natriuretic peptides such as BNP. Such methods and compositions can provide early indications of a deterioration in cardiorenal syndrome status, including prognosis regarding mortality and worsening renal function.
Claims10
A method of assigning a risk of worsening renal function to a patient suffering from heart failure, comprising:
- performing an assay method that detects NGAL (neutrophil gelatinase-associated lipocalin) on a body fluid sample obtained from said patient, thereby providing an NGAL assay result;
- comparing said NGAL assay result to a baseline NGAL result;
- and
- relating the NGAL assay result to the patient's risk of worsening renal function by assigning an increased risk of worsening renal function to said patient when said NGAL assay result is greater than said baseline NGAL result, relative to a risk assigned when said NGAL assay result is less than said baseline NGAL result, or by assigning a decreased risk of worsening renal function to said patient when said NGAL assay result is less than said baseline NGAL result, relative to a risk assigned when said NGAL assay result is greater than said baseline NGAL result.
Dependencies are inferred from the claim text.