Isolated genomic polynucleotide fragments from chormosome 19 that encode human syntaxin binding protein 2
AssigneeRyogen LLC
InventorJames Ryan
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Abstract
The invention is directed to isolated genomic polynucleotide fragments that encode human resistin and human syntaxin binding protein 2, vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain human resistin and human syntaxin binding protein 2 and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
Claims27
An isolated nucleic acid molecule consisting of a non-coding region of a nucleic acid molecule consisting of a nucleic acid sequence which has at least 99% identity to the nucleic acid molecule of SEQ ID NO:4 and which encodes a polypeptide having the amino acid sequence of SEQ ID NO:2, wherein said polypeptide binds to syntaxins 1A, 2 and 3 but not to syntaxin 4, which non-coding region is selected from the group consisting of a 5′-noncoding region shown in sequence segment 19052-64700 of SEQ ID NO:4, a 3′-non coding region shown in sequence segment 1-8391 of SEQ ID NO:4 and an intron region shown in sequence segments 17477-19015, 17183-17425, 16472-17101, 15471-16393, 15303-15392, 14503-15203, 14167-14346, 13999-14082, 13775-13869, 13435-13666, 13222-13377, 13037-13152, 11591-12958, 11006-11449, 9953-10894, 9040-9856, 8850-8955 and 8478-8690 of SEQ ID NO:4, or a full complement of said isolated nucleic acid molecule.
An isolated nucleic acid molecule consisting of a fragment of a nucleic acid molecule consisting of a nucleic acid sequence which has at least 99% identity to the nucleic acid molecule of SEQ ID NO:4 and which encodes a polypeptide having the amino acid sequence of SEQ ID NO:2, wherein said polypeptide binds to syntaxins 1A, 2 and 3 but not to syntaxin 4, wherein said fragment consists of a nucleic acid sequence selected from the group consisting of:
- (a) a sequence of at least 4000 contiguous nucleotides within a region consisting of the sequence of nucleotides from position 19052-64700 of SEQ ID NO:3
- (b) a sequence of a least 600 contiguous nucleotides with the region consisting of the sequence of nucleotides from position 1-8390 of SEQ ID NO:3 or a full complement of said isolated nucleic acid molecule and
- (c) a full complement of (a) or (b).
An isolated nucleic acid molecule consisting of 20-300 contiguous nucleotides in sequence segments of a non-coding region of a nucleic acid molecule consisting of a nucleic acid sequence which has at least 99% identity to the nucleic acid molecule of SEQ ID NO:4 and which encodes a polypeptide having the amino acid sequence of SEQ ID NO:2, wherein said polypeptide binds to syntaxins 1A, 2 and 3 but not to syntaxin 4, which non-coding region is selected from the group consisting of a 5′-noncoding region shown in sequence segment 19052-64700 of SEQ ID NO:4, a 3′-non coding region shown in sequence segment 1-8391 of SEQ ID NO:4 and an intron region shown in sequence segments 17477-19015, 17183-17425, 16472-17101, 15471-16393, 15303-15392, 14503-15203, 14167-14346, 13999-14082, 13775-13869, 13435-13666, 13222-13377, 13037-13152, 11591-12958, 11006-11449, 9953-10894, 9040-9856, 8850-8955 and 8478-8690 of SEQ ID NO:4, or a full complement of said isolated nucleic acid molecule.
Dependencies are inferred from the claim text.