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US 8,282,967 B2Granted
Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
AssigneeThe University of North Carolina at Chapel Hill
InventorsMark H. Schoenfisch, Jae Ho Shin, Nathan Stasko
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Abstract
The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
Claims11
A nitric oxide-releasing particle, the nitric oxide-releasing particle comprising:
- a co-condensed silica network comprising a nitric oxide donor, wherein the nitric oxide donor is formed prior to condensation of the co-condensed silica network, wherein the co-condensed silica network is synthesized from the condensation of a silane mixture comprising an alkoxysilane and at least one aminoalkoxysilane having an amine substituted by a diazeniumdiolate.
Dependencies are inferred from the claim text.