Method of preparing a microcapsule containing unsaturated fatty acids, the microcapsule prepared by the method, and articles containing the microcapsule

#This application is a 35 U.S.C. §371 National Phase Entry Application from PCT/KR2007/003623, filed Jul. 27, 2007, and designating the United States, which claims priority under 35 U.S.C. §119 to Korean Patent Application No. 10-2006-0076966 filed Aug. 16, 2006, which is incorporated herein in its entirety.

#The present invention relates to a preparing method of microcapsule containing unsaturated fatty acids, a microcapsule prepared by the method, and articles containing the microcapsule.

#Unsaturated fatty acid is a fatty acid containing one or more double bonds, and mostly is liquid at room temperature. Highly unsaturated fatty acid generally indicates a fatty acid containing four or more double bonds per molecule, and recently, many physiological functions thereof have been reported. Particularly, an omega 3-fatty acid in unsaturated fatty acids exists in nerve cell membrane and retina, and plays a role to rapidly transfer electric stimulus from a cell membrane to another cell. It has been reported that an omega 3-fatty acid has an effect to protect cells in body, keep the structure of cells, and help the metabolism smoothly. Also, it has been reported that an omega 3-fatty acid is effective for inhibiting formation of membrane of blood, and stimulating formation of bones and strengthening bones at the same time.

#FIG. 1 represents a scheme of the preparing method of the microcapsules containing unsaturated fatty acids according to the present invention.

#FIG. 2 represents values of CLA content of CLA microcapsule prepared in Example 1.

#FIG. 3 represents a photo of a tablet containing CLA microcapsule prepared in Example 3.

#The following examples are intended to further illustrate the present invention, and the scope of the present invention is not intended to be limited thereby in any way.

#Xanthan gum (Sigma) of 1.5 g, poly glycerin esters of fatty acids (Ilshinwells Co., Ltd, Almax 9060) of 0.5 g and locust bean gum (Sigma) of 0.1 g were mixed with sterile water of 50 g in a gelatification bowl. And, the solution was gelatificated at 120° C. for 5 min, and was cooled to 60° C. Then, CLA (95%, Lipozen) of 6.3 g (w/w) was added to the solution, and homogenized at 6,400 rpm and 40° C. (Water Bath, VISION) for 5 min by a homogenizer (IKA T-50) to obtain a first coating material.

#Modified starch (LOSTAR, Cornproducts Korea Inc.) of 0.3 g and gelatin (SAMMI INDUSTRIAL CO., LTD) of 3.0 g, poly glycerin esters of fatty acids (Almax 9080) of 0.5 g, and sterile water of 100 g were mixed in a gelatification bowl, and gelatificated at 120° C. for 5 min. And, the solution was cooled to 40° C., and the first coating material was added to the solution. After that, the solution was homogenized at 6,400 rpm, for 5 min by a homogenizer (IKA T-50) to obtain a second coating material. The second coating material of 827 g was sprayed directly in sterilized cool water to prepare a CLA microcapsule.