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AssigneesNational Institute of Infectious Diseases, National University Corporation Hokkaido University, Saitama Medical University, Nof Corporation
InventorsTetsuya Uchida, Maiko Taneichi, Kiichi Kajino, Masanori Matsui, Hiroshi Oda
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The present invention provides an avian influenza vaccine containing a peptide-bound liposome wherein; the peptide contains: (1) an amino acid sequence shown by any one of SEQ ID NO:1 to 9, or (2) an amino acid sequence shown by any one of SEQ ID NO:1 to 9 wherein one or two amino acids are substituted, has a length of 9 to 11 amino acids, and is capable of inducing HLA-restricted cytotoxic T lymphocytes; wherein the liposome contains a phospholipid having an acyl group with 14 to 24 carbon atoms and one unsaturated bond or a hydrocarbon group with 14 to 24 carbon atoms and one unsaturated bond, and a liposome stabilizer; and wherein the peptide is bound to the surface of the liposome.
An immunogenic composition comprising a peptide-bound liposome and a pharmaceutically acceptable carrier, wherein the peptide-bound liposome comprises:
An avian influenza virus vaccine comprising a peptide-bound liposome comprising:
A method of activating cytotoxic T lymphocytes in a mammal, comprising administering to the mammal a peptide-bound liposome comprising:
A method of vaccinating a mammal against avian influenza virus, comprising administering to the mammal a peptide-bound liposome comprising:
A peptide-bound liposome comprising:
Dependencies are inferred from the claim text.