Human papillomavirus vaccine for oral administration
AssigneesAsahi Glass Company, Limited, National University Corporation Kanazawa University
InventorsToshiyuki Sasagawa, Hideki Tohda, Yuko Hama
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Abstract
The object of the present invention is to provide an edible vaccine which is effective for human papilloma virus (HPV) type 16 and available in large amounts inexpensively. An edible human papilloma virus vaccine obtained by culturing a transformant of an avirulent fission yeast host, wherein the transformant carries a gene encoding an antigenic protein of human papilloma virus introduced therein and accumulates the expressed antigenic protein in it.
Claims19
A method for orally priming a subject's immune system comprising:
- orally administering a freeze-dried recombinant Schizosaccharomyces pombe avirulent fission yeast that expresses or accumulates within it an exogenous protein of human papilloma virus to a subject in need thereof in an amount effective to induce an immune response against human papilloma virus.
A method for orally priming a subject's immune system against subsequent exposure to a human papilloma virus antigen comprising:
- orally administering to a subject in need thereof a freeze-dried recombinant Schizosaccharomyces pombe avirulent fission yeast that expresses or accumulates within it an exogenous protein of human papilloma virus in an amount effective to prime the immune system of the subject against subsequent exposure to said protein of human papilloma virus.
A method for inducing antibodies to HPV comprising:
- orally priming a subject's immune system with a priming antigen, and
- boosting the primed subject with the priming antigen;
- wherein said priming antigen comprises a freeze-dried recombinant Schizosaccharomyces pombe avirulent fission yeast that expresses or accumulates within it an exogenous protein of human papilloma virus.
Dependencies are inferred from the claim text.