Molecular delivery vehicle
AssigneeThe University of Queensland
InventorsRobert Glenn Parton, Piers Jamie Waiser
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Abstract
An isolated caveolin containing vesicle comprising a caveolin protein and at least one lipid, wherein at least about 30% of the at least one lipid is selected from phosphatidylethanolamine and phosphatidylglycerol is disclosed. Also disclosed is a method of making an isolated caveolin containing vesicle, an isolated caveolin containing vesicle comprising a recombinant caveolin protein, an isolated caveolin containing delivery vesicle, a method of making an isolated caveolin containing delivery vesicle and a method of treatment of a disease or condition by delivery of a molecule using the isolated caveolin containing delivery vesicle.
Claims46
An isolated caveolin containing vesicle comprising a caveolin protein and at least one lipid, wherein at least about 30% of the at least one lipid is selected from phosphatidylethanolamine and phosphatidylglycerol.
A method of making an isolated caveolin containing vesicle including the step of allowing a caveolin protein to associate with at least one lipid, wherein at least about 30% of the at least one lipid is selected from phosphatidylethanolamine and phosphatidylglycerol, to thereby make the isolated caveolin containing vesicle.
An isolated caveolin containing vesicle comprising a recombinant caveolin protein expressed in a prokaryote associated with at least one lipid;
- wherein the recombinant caveolin protein and the at least one lipid associate in the prokaryote.
A method of making an isolated caveolin containing vesicle including the steps of:
- expressing a recombinant caveolin protein in a prokaryote;
- and allowing the expressed recombinant caveolin protein to associate with at least one lipid in the prokaryote;
- to thereby make the isolated caveolin containing vesicle.
An isolated caveolin containing delivery vesicle comprising:
- a caveolin protein;
- at least one lipid;
- wherein at least about 30% of the at least one lipid is selected from phosphatidylethanolamine and phosphatidylglycerol;
- and a molecule to be delivered by the vesicle.
A method of making an isolated caveolin containing delivery vesicle, the method including the step of allowing a caveolin protein to associate with at least one lipid and a molecule to be delivered by the vesicle, wherein at least about 30% of the at least one lipid is selected from phosphatidylethanolamine and phosphatidylglycerol, to thereby make the isolated caveolin containing delivery vesicle.
A method of making an isolated caveolin containing delivery vesicle, the method including the steps of:
- co-expressing a caveolin protein and a molecule to be delivered;
- and allowing the caveolin protein to associate with at least one lipid and the molecule to be delivered by the vesicle;
- to thereby make the isolated caveolin containing delivery vesicle.
A composition comprising an isolated caveolin containing delivery vesicle and a pharmaceutically acceptable carrier, diluent or excipient,
- wherein the isolated caveolin containing delivery vesicle is made by a method comprising allowing the caveolin protein to associate with at least one lipid and the molecule to be delivered by the vesicle, wherein at least about 30% of the at least one lipid is a phosphatidylethanolamine, a phosphatidylglycerol or a combination thereof.
Dependencies are inferred from the claim text.