Tumor therapy with replication competent sindbis viral vectors
AssigneeNew York University
InventorsDaniel Meruelo, Jen-Chieh Tseng
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Abstract
Disclosed herein are methods for treating a mammal harboring a solid tumor which expresses higher levels of High Affinity Laminin Receptors (LAMR) than normal cells of the same lineage comprising systematically administering to a mammal in need of such treatment a therapeutically effective amount of a Replication Competent (RC) Sindbis virus vector, wherein said vector encodes a suicide gene.
Claims12
A method for treating a mammal harboring a solid tumor which expresses higher levels of High Affinity Laminin Receptors (LAMR) than normal cells of the same lineage comprising intraperitoneally administering to a mammal in need of such treatment a therapeutically effective amount of a Replication Competent (RC) Sindbis virus vector and a therapeutically effective amount of a prodrug, wherein said vector encodes a suicide gene, and wherein said RC Sindbis virus vector is a RC mut-4 vector comprising SEQ. ID NOS.:
- 2-8 and said administration causes reduction in size of said tumor.
A method for treating a mammal harboring a solid tumor which expresses higher levels of High Affinity Laminin Receptors (LAMR) than normal cells of the same lineage comprising parenterally administering to a mammal in need of such treatment a therapeutically effective amount of a Replication Competent (RC) Sindbis virus vector, wherein said vector encodes a suicide gene and, wherein said RC Sindbis virus vector is a RC mut-4 vector comprising SEQ. ID NOS.:
- 2-8, and said administration causes a reduction in tumor size.
Dependencies are inferred from the claim text.