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US 8,282,888 B2Granted
Method and apparatus for the use of [11C] carbon monoxide in labeling synthesis by photo-initiated carbonylation
AssigneeGe Healthcare Limited
InventorsTor Kihlberg, Oleksiy Itsenko, Tommy Ferm, Bengt Langstrom
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Abstract
Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
Claims4
A system for labeling synthesis, comprising:
- (a) a UV reactor assembly comprising a high pressure reaction chamber,
- (b) a UV lamp, and
- (c) a concave mirror,
- wherein the high pressure reaction chamber having a window facing the concave mirror, a liquid inlet and a gas inlet in a bottom surface thereof, wherein the concave minor can focus the UV light from the UV lamp, and the focused light beam enters the window of the reaction chamber.
1 more element
Dependencies are inferred from the claim text.