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US 8,277,818 B2Granted
Herpes virus strains for gene therapy
AssigneeBiovex Limited
InventorRobert S. Coffin
Life of this patent
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Abstract
The present invention provides a herpes virus with improved oncolytic properties which comprises a gene encoding an immunomodulatory cytokine and which lacks a functional ICP34.5 gene and a functional ICP47 encoding gene.
Claims1
A pharmaceutical composition comprising as active ingredient a virus wherein the virus is derived from HSV1 JSI as deposited at the European collection of cell cultures (ECAAC) under accession number 01010209 and wherein the virus
- (i) comprises GM-CSF;
- (ii) lacks a functional 1CP34,5 encoding gene and a functional ICP47 encoding gene;
- and
- (iii) is replication competent in infected tumor cells;
- and a pharmaceutically acceptable carrier or diluent.
2 more elements
Dependencies are inferred from the claim text.