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AssigneesMassachusetts Institute of Technology, President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
InventorsMatteo Iannacone, Frank Alexis, Pamela Basto, Elliott Ashley Moseman, Jinjun Shi, Robert S. Langer, Omid C. Farokhzad, Ulrich von Andrian, Elena Tonti
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The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune system response in the form of antibody production, wherein the nanocarriers lack any T cell antigens. In some embodiments, the invention provides nanocarriers that comprise an immunofeature surface, which provides high avidity binding of the nanocarriers to antigen presenting cells. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
A composition comprising pharmaceutically acceptable synthetic nanocarriers comprising an immunofeature surface formed of a scaffold having bound thereto a plurality of B-cell antigen moieties, the immunofeature surface binding with high avidity and low affinity to antigen presenting cells, and an immunostimulatory or immunomodulatory agent to be delivered to the antigen presenting cells (APCs), wherein the nanocarriers contain less than 10 mol % of a T-helper antigen.
Dependencies are inferred from the claim text.