Process for preparing tamsulosin hydrochloride
AssigneeAvrobindo Pharma Ltd.
InventorsAnand Gopalkrishna Kamat, Narsimha Reddy Penthala, Sivakumaran Meenakshisunderam
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Abstract
The invention relates to an process for preparing Tamsulosin hydrochloride of Formula (I) which comprises (i) reacting (R)-(−)-5-(2-amino-propyl)-2-methoxybenzenesulfonamide of Formula (II) with substituted phenoxy compound of Formula (III), wherein Z represents a removing group, such as —OSO2CH3, —OSO2C6H4CH3, —F, —Br, —Cl, or —I, in a solvent in the presence of an alkaline earth metal oxide to obtain Tamsulosin base and (ii) converting Tamsulosin base into hydrochloride salt in a solvent by addition of aqueous hydrochloric acid.
Claims7
An improved process to prepare Tamsulosin hydrochloride of Formula I
- which comprises
- (i) reacting (R)-(−)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide of Formula II,
- with substituted phenoxy compound of Formula III,
- wherein Z represents a leaving group selected from —OSO2CH3, —SO2C6H4CH3, —F, —Br, —Cl, or —I, in a solvent in the presence of an alkaline earth metal oxide to obtain Tamsulosin base;
- and
- (ii) converting Tamsulosin base into hydrochloride salt in a solvent by addition of aqueous hydrochloric acid.
Dependencies are inferred from the claim text.