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US 8,273,905 B2Granted
Aminoalkyl-amidomethyl-substituted 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2H-chroman-6-yl derivatives
AssigneeAbbott Products GmbH
InventorsBrian Moloney, Lester Marrison, Dieter Ziegler, Michael Mlinaric, Christiane Boecker, Reinhard Brueckner, Michael Weske, Klaus Witte, Yvan Fischer
Life of this patent
Estimating the term…
Abstract
Compounds corresponding to formula I, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n have the meanings given in the description, and also a process for the preparation of these compounds and intermediate products of this process. Furthermore, pharmaceutical compositions comprising the compounds of Formula I and related methods of treatment.
Claims13
A compound corresponding to formula I,
- wherein
- R1 is C1-4-alkyl;
- R2 is C1-4-alkyl;
- R3 is phenyl which is optionally substituted 1 to 3 times by any of halogen, C1-6-alkyl or C1-4-alkoxy;
- R4 is hydrogen;
- C1-6-alkyl or C3-7-cycloalkyl-C1-4-alkyl,
- R6 is hydrogen;
- and
- R7 is hydrogen;
- and
- R8 is hydrogen;
- and
- R10 is C1-6-alkyl;
- phenyl-C0-4-alkyl or pyridinyl-C0-4-alkyl;
- provided that R10 is not phenyl when R5 and R9 together form C2-alkylene;
- R5 and R9 together form C1-3-alkylene;
- and
- n is 0 or 1,
- or a physiologically compatible salt thereof.
16 more elements
A process for the preparation of a compound corresponding to Formula I,
- wherein
- R1 is C1-4-alkyl;
- R2 is C1-4-alkyl;
- R3 is phenyl which is optionally substituted 1 to 3 times by any of halogen, C1-6-alkyl or C1-4-alkoxy;
- R4 is hydrogen;
- C1-6-alkyl or C3-7-cycloalkyl-C1-4-alkyl,
- R6 is hydrogen;
- and
- R7 is hydrogen;
- and
- R8 is hydrogen;
- and
- R10 is C1-6-alkyl;
- phenyl-C0-4-alkyl or pyridinyl-C0-4-alkyl;
- with the proviso that R10 is not phenyl when R5 and R9 together form C2-alkylene;
- R5 and R9 together form C1-3-alkylene;
- and
- n is 0 or 1,
- or a physiologically compatible salt thereof,
- said method comprising the steps of reacting
- a) a compound corresponding to the general Formula II,
- wherein R1, R2, R4, R5, R6, R7, R8, R9, R10 and n have the above meanings, with a compound of the general formula III,
- X—SO2—R3 III
- wherein R3 has the above meaning, and X is a cleavable leaving group, or
- reacting
- b) a compound corresponding to general Formula IV
- wherein R1, R2, R3 and R4 have the above meanings, with a compound corresponding to general Formula V,
- wherein R5, R6, R7, R8, R9, R10 and n have the above meanings, and optionally converting resulting free compounds corresponding to Formula I into their physiologically compatible salts, or converting salts of the compounds corresponding to Formula I into free compounds corresponding to Formula I.
25 more elements
A compound corresponding to formula II,
- wherein
- R1 is C1-4-alkyl;
- R2 is C1-4-alkyl;
- R4 is hydrogen;
- C1-6-alkyl or C3-7-cycloalkyl-C1-4-alkyl,
- R6 is hydrogen;
- and
- R7 is hydrogen;
- and
- R8 is hydrogen;
- and
- R10 is C1-6-alkyl;
- phenyl-C0-4-alkyl or pyridinyl-C0-4-alkyl;
- with the proviso that R10 is not phenyl when R5 and R9 together form C2-alkylene;
- or
- R5 and R9 together form C1-3-alkylene;
- and
- n is 0 or 1
- or a salt or solvate thereof.
16 more elements
Dependencies are inferred from the claim text.