US 8,273,899 B2 · Method for production of N-(2-amino-1,2-dicyanovinyl)imidates, method for production of N-(2-amino-1,2-dicyanovinyl)formamidine, and method for production of aminoimidazole derivatives

Abstract

A method for producing N-(2-amino-1,2-dicyanovinyl)imidates represented by the following formula (1-III) under low temperature conditions within a short period of time in high yield is provided. In addition, a method for producing N-(2-amino-1,2-dicyanovinyl)formamidine represented by the following formula (2-II) which is suitably applicable to a cyclization reaction for producing AICN, AICA or the like and which enhances yield of the cyclization reaction is provided. In addition, a method for producing aminoimidazole derivatives represented by the following formula (3-V) in high yield by using diaminomaleonitrile as a starting material is provided.

Claims5

Dependent claims

A method for producing N-(2-amino-1,2-dicyanovinyl)imidates of the following formula (1-III):

the method comprising;
reacting, in the presence of a strong acid, diaminomaleonitrile with a compound represented by the following formula (1-II):
CR1(OR2)3 (1-II)
wherein:
R1 is a hydrogen atom, an optionally substituted alkyl group, or an optionally substituted aryl group;
each R2 is independently an optionally substituted alkyl group, or an optionally substituted aryl group;
and
a reaction temperature ranges from 30 to 50° C.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application

12/450,730Filed 17 Apr 2008

Priority

JP 2007-11103819 Apr 2007

Published

US 2010/0087655 A18 Apr 2010

Granted

25 Sep 2012

Term ends

Not estimatedThe source records don’t support an estimate.

Classification5 codes

C07D 233/90
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…
C07C 257/06
Without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers: having carbon atoms of imino-carboxyl groups bound to…
C07C 257/12
With replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines: having carbon atoms of amidino groups bound to…
C07D
Heterocyclic compounds

Method for production of N-(2-amino-1,2-dicyanovinyl)imidates, method for production of N-(2-amino-1,2-dicyanovinyl)formamidine, and method for production of aminoimidazole derivatives

Life of this patent

Method for production of N-(2-amino-1,2-dicyanovinyl)imidates, method for production of N-(2-amino-1,2-dicyanovinyl)formamidine, and method for production of aminoimidazole derivatives

Life of this patent

Abstract

Claims5