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US 8,273,896 B2Granted
Processes for producing phenyl-6-(1-(phenyl)ureido)nicotinamides
AssigneeVertex Pharmaceutical Incorporated
InventorsStefanie Roeper, Adam R. Looker, Theodore A. Martinot, Bobbianna Neubert-Langille, Michael P. Ryan, John R. Snoonian
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Abstract
The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
Claims6
A process for preparing Compound 10
- comprising coupling Compound 11
- with Compound 6
- by dissolving Compounds 11 and 6 in Methyl tert-butylether (MTBE), treating the mixture with a base and stirring the mixture at a temperature of about −8° C. to −10° C. to obtain Compound 9
- treating Compound 9 with triphosgene and diisopropylethylamine in the presence of tetrahydrofuran;
- stirring the solution;
- and treating the solution with anhydrous ammonia.
3 more elements
Dependencies are inferred from the claim text.