Processes for synthesis of opiate alkaloid derivatives

A process for the preparation of a compound of Formula (III), the process comprising a first reaction that comprises contacting a compound of Formula (I) with an aprotic solvent and a dienophile to form a compound of Formula (II), and then a second reaction that comprises contacting the compound of Formula (II) with a catalyst, hydrogen, and the aprotic solvent to form a compound of Formula (III) according to the following reaction scheme:

• wherein:
• R1 and R8 are independently selected from the group consisting of hydrocarbyl and substituted hydrocarbyl;
• R2 and R3 are independently selected from the group hydrogen, hydrocarbyl and substituted hydrocarbyl;
• R4 and R5 are independently selected from the group consisting of hydrogen, hydrocarbyl, substituted hydrocarbyl, halogen, {—}OH, {—}NH2, {—}SH, {—}SR8, and {—}OR8;
• R6 and R7 are independently selected from the group consisting of hydrogen, a protecting group, hydrocarbyl, and substituted hydrocarbyl;
• and
• X is oxygen, and
• wherein the first reaction and the second reaction are both conducted in a one-pot process;
• and the aprotic solvent used for the first reaction and the aprotic solvent for the second reaction are the same.