Phenazine compounds and use thereof in autoimmune and inflammatory diseases
AssigneeJJ Pharma, Inc.
InventorJosefino B. Tunac
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Abstract
The invention discloses compounds, compositions and methods useful for preventing and/or treating autoimmune diseases and inflammatory diseases. The methods and compositions utilize water-soluble phenazine compounds, or salts, or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent autoimmune diseases and inflammatory diseases such as those caused by arthritis and rheumatoid arthritis.
Claims9
A compound of Formula II:
- wherein R1 is lower alkyl consisting of 1 to 10 carbon atoms, halo-lower alkyl, lower alkenyl, lower alkynyl, lower alkylamino, cycloalkyl, or heteroaryl;
- and M+ is Na+ or K+.
A method of preparing a compound of Formula II:
- wherein R1 is lower alkyl consisting of 1 to 10 carbon atoms, halo-lower alkyl, lower alkenyl, lower alkynyl, lower alkylamino, cycloalkyl, or heteroaryl;
- and M+ is Na+ or K+, the method comprising:
- i) growing Lysobacter antibioticus in agar culture medium at a pH range of 4 to 9 and at a temperature range of 15° C. to 37° C.;
- ii) inoculating a production culture medium with Lysobacter antibioticus;
- iii) culturing at a pH range of 4 to 9 and at a temperature range of 15° C. to 37° C. with continuous agitation and aeration;
- iv) adding aqueous M+OH−, wherein M+ is Na+ or K+;
- and
- v) recovering the compound of Formula II by centrifugation.
A method of treating a subject for rheumatoid arthritis or osteoarthritis, the method comprising administering to the subject an effective amount of a compound of Formula II:
- wherein R1 is lower alkyl consisting of 1 to 10 carbon atoms, halo-lower alkyl, lower alkenyl, lower alkynyl, lower alkylamino, cycloalkyl, or heteroaryl;
- and M+ is Na+ or K+.
Dependencies are inferred from the claim text.