Compositions and methods for inhibiting viral replication
AssigneeAlnylam Pharmaceuticals, Inc.
InventorsMatthias John, Stefan Limmer, Hans-Peter Vornlocher, Roland Kreutzer
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Abstract
The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3′-untranslated region (3′-UTR) of a (+) strand RNA virus, such as HCV, as well as pharmaceutical compositions comprising the dsRNA, together with a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for treating infections and diseases caused by the replication or activity of the (+) strand RNA virus, as well as methods for inhibiting viral replication.
Claims24
A double-stranded ribonucleic acid (dsRNA) for inhibiting the replication of a (+) strand RNA virus, wherein the dsRNA comprises a sense RNA strand consisting of a nucleotide sequence which is substantially identical to a 3′-untranslated region (3′-UTR) of the (+) strand RNA virus and an antisense RNA strand which is complementary to at least a part of the sense RNA strand, and wherein each strand of the dsRNA is 21 to 24 nucleotides in length, and wherein one of the strands of the dsRNA is complementary to at least a portion of a strand comprising SEQ ID NO:1.
A pharmaceutical composition for inhibiting the replication of a (+) strand RNA virus in an mammal, comprising a dsRNA and a pharmaceutically acceptable carrier, wherein the dsRNA comprises a sense RNA strand consisting of a nucleotide sequence which is substantially identical to a 3′-untranslated region (3′-UTR) of the (+) strand RNA virus and an antisense RNA strand which is complementary to at least a part of the sense RNA strand, and wherein each strand of the dsRNA is 21 to 24 nucleotides in length, and wherein one of the strands of the dsRNA is complementary to at least a portion of a strand comprising SEQ ID NO:1.
Dependencies are inferred from the claim text.