Multivalent clostridial toxins

A polynucleotide molecule encoding a multivalent Clostridial toxin, wherein the multivalent Clostridial toxin comprises:

• a) a Clostridial toxin enzymatic domain capable of executing an enzymatic target modification step of a Clostridial toxin intoxication process;
• b) a Clostridial toxin translocation domain capable of executing a translocation step of a Clostridial toxin intoxication process;
• c) a first binding domain capable of executing a cell binding step of a Clostridial toxin intoxication process by selectively binding a first cell surface receptor displayed by the target cell;
• d) a second binding domain capable of executing a cell binding step of a Clostridial toxin intoxication process by selectively binding a second cell surface receptor displayed by the target cell;
• and
• e) a protease cleavage site, wherein cleavage of the protease cleavage site converts the single-chain form of the modified Clostridial toxin into the di-chain form.