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US 8,273,858 B2Granted
Polypeptide compounds for inhibiting angiogenesis and tumor growth
AssigneeVasGene Therapeutics, Inc.
InventorsValery Krasnoperov, Nathalie Kertesz, Ramachandra Reddy, Parkash Gill, Sergey Zozulya
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Abstract
In certain embodiments, this present invention provides polypeptide compositions, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.
Claims22
An isolated monoclonal antibody or antigen-binding portion thereof that binds to an epitope situated in the extracellular portion of EphB4, promotes apoptosis, and inhibits an EphB4 activity.
Dependencies are inferred from the claim text.