Tetra calcium phosphate based organophosphorus compositions and methods
AssigneeHowmedica Osteonics Corp.
InventorsVenkat R. Garigapati, Brian J. Hess, Jon Ahola
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Abstract
Compositions and methods of their use to adhere a variety of materials together are disclosed herein. The compositions include at least tetra calcium phosphate, an effective amount of a compound that is structurally similar to phosphoserine, and can be mixed with an aqueous solution. The compositions provide adhesive and cohesive strength in both wet and dry environments and exhibit significant bond strength upon curing.
Claims35
A method of repairing a hard surface comprising the steps of:
- mixing a composition comprising an effective amount of tetra calcium phosphate and a compound of the formula
- where A is O, CH2, or S;
- R is H, NH2, NHCO(CH2)tCH3 where t is 0 to 2, NH(CH2)xCH3 where x is 0 to 3, NR1R2 where R1 is (CH2)yCH3 and R2 is (CH2)yCH3 where y is 0 to 2, (CH2)zCH3 where z is 0 to 3, where m is 0 to 1, and where n is 0 to 3 and wherein the compound is present in an amount from about 10% to about 90% by weight based on the combined weight of the tetra calcium phosphate and the compound,
- with sufficient aqueous medium to create a mixture;
- applying the mixture to the hard surface to be repaired;
- and
- allowing the mixture to cure.
A method of repairing bone structure comprising the steps of:
- applying a composition comprising an effective amount of tetra calcium phosphate and a compound of the formula
- where A is 0, CH2, or S;
- R is H, NH2, NHCO(CH2)1CH3 where t is 0 to 2, NH(CH2)xCH3 where x is 0 to 3, NR1R2 where R1 is (CH2)yCH3 and R2 is (CH2)yCH3 where y is 0 to 2, (CH2)zCH3 where z is 0 to 3, where m is 0 to 1, and where n is 0 to 3 and wherein the compound is present in an amount from about 10% to about 90% by weight based on the combined weight of the tetra calcium phosphate and the compound directly to the bone structure to be repaired;
- and
- allowing the composition to harden by combining in situ with aqueous based bodily fluids.
A method of joining bone to another material comprising the steps of:
- mixing a composition comprising an effective amount of tetra calcium phosphate and a compound of the formula
- where A is 0, CH2, or S;
- R is H, NH2, NHCO(CH2)tCH3 where t is 0 to 2, NH(CH2)xCH3 where x is 0 to 3, NR1R2 where R1 is (CH2)yCH3 and R2 is (CH2)yCH3 where y is 0 to 2, (CH2)zCH3 where z is 0 to 3, where m is 0 to 1, and where n is 0 to 3 and wherein the compound is present in an amount from about 10% to about 90% by weight based on the combined weight of the tetra calcium phosphate and the compound, with sufficient aqueous medium to create a mixture;
- applying the mixture to a surface of the bone;
- placing the surface of the bone into contact with a material to be joined to the bone;
- and
- allowing the mixture to cure.
Dependencies are inferred from the claim text.