Tamper resistant lipid-based oral dosage form for opioid agonists
AssigneeShear Kershman Laboratories, Inc.
InventorsJames M. Bausch, Alvin Kershman, Jeff L. Shear, Linda L. Lewis
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Abstract
A tamper resistant drug delivery system made of at least one lipid, at least one gelling agent and at least one drug active, such as oxycodone, where the system gels rapidly in the presence of water or a solution containing water, and the drug active releases into the digestive system, wherein the weight ratio of gelling agent to lipid is less than 1:1.4.
Claims20
A tamper-resistant drug delivery system comprising at least one lipid, at least one gelling agent and at least one drug active, wherein the gelling agent rapidly gels in the presence of water in about 10 seconds or less, wherein the drug active releases into the digestive system in about 10 minutes or less, wherein the weight ratio of gelling agent to lipid is less than 1:1.4, wherein the lipid is not a fatty acid, and wherein the lipid is present in the delivery system from about 20 wt. % to 50 wt. %.
A tamper-resistant drug delivery system comprising at least one lipid, at least one gelling agent and at least one drug active, wherein the gelling agent rapidly gels in about 10 seconds or less in the presence of water, and the drug active releases into the digestive system in about 10 minutes or less, and wherein the weight ratio of gelling agent to lipid is less than 1:1.4, wherein the system contains at least one disintegrating agent and at least one surfactant, wherein the drug active includes an opioid, wherein the lipid is not a fatty acid, and wherein the lipid is present in the delivery system from about 20 wt. % to 50 wt. %.
A solid tamper-resistant drug delivery system comprising at least one lipid, at least one gelling agent and the pharmaceutically acceptable salt of at least one drug active, wherein the gelling agent rapidly gels in about 10 seconds or less in the presence of water, and the drug active releases into the digestive system in about 10 minutes or less, and wherein the weight ratio of gelling agent to lipid is less than 1:1.4, wherein the system contains at least one disintegrating agent;
- and at least one surfactant, wherein the lipid is not a fatty acid, and wherein the lipid is present in the delivery system from about 20 wt. % to 50 wt. %.
Dependencies are inferred from the claim text.