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US 8,273,788 B2Granted
Five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis therapeutics
AssigneeAcademia Sinica, a Taiwan corporation
InventorsPi-Hui Liang, Yi-Ling Lin, Chi-Huey Wong
Life of this patent
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Abstract
Novel 5-membered iminocyclitol derivatives were found to be a potent and selective inhibitors of the glycoprotein processing α- and β-glucosidase which were further found to be active antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN-2), human SARS coronavirus and human β-hexosaminidase, a new target for development of osteoarthritis therapeutics.
Claims5
An inhibitor of hexoaminidase or glucosidase represented by the following structure:
- wherein m is an integer ranging from 6-8.
An inhibitor of hexoaminidase or glucosidase represented by the following structure:
Dependencies are inferred from the claim text.