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AssigneeOnconova Therapeutics, Inc.
InventorsStanley C Bell, Glenn Fegley, Stephen Cosenza, Jodie Duke, Reddy E Premkumar, Reddy M. V. Ramana
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Activated cytotoxic compounds are described for attachment to targeting molecules for the treatment of a mammalian disease condition which comprise, an activator, a spacer linker, a linker (e.g., self-immolative), and a cytotoxic drug selected from the group consisting of AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES, AMINO-AND-HYDROXY SUBSTITUTED STYRYLSULFONANILIDES, and SUBSTITUTED PHENOXY- AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES. Activated cytotoxic compound attached to a targeting molecule are described wherein the targeting molecule is selected from the group consisting essentially of an antibody, a receptor, a ligand, a cytokine, a hormone, and a signal transduction molecule. The invention is further directed to a method of treatment of disease conditions.
An activated cytotoxic compound for attachment to a targeting molecule for the treatment of proliferative disorders comprising, an activator, a spacer linker, a linker, and a cytotoxic drug wherein the linker is a self-immolative linker is para-Aminobenzyl Alcohol (PABA), 3,3-Dimethyl-4-hydroxybutyric Acid, an Ethylenediamine, γ-Aminobutyric Acid (GABA), 2-Hydroxycinnamic Acid, “Trimethyl Lock”, or an Ethanolamine and the spacer linker comprises Glutaryl, Diglycoyl, Succinyl, Homophthalyl, or Amino-PEG-Acid;
An activated cytotoxic compound for attachment to a targeting molecule that binds a specific biological target for the treatment of proliferative disorders comprising a target molecule covalently attached to an activator, a spacer linker, a self-immolative linker, and a cytotoxic drug, wherein the self-immolative linker is para-Aminobenzyl Alcohol (PABA), 3,3-Dimethyl-4-hydroxybutyric Acid, an Ethylenediamine, γ-Aminobutyric Acid (GABA), 2-Hydroxycinnamic Acid, “Trimethyl Lock”, or an Ethanolamine, and the spacer linker is Glutaryl, Diglycoyl, Succinyl, Homophthalyl, or Amino-PEG-Acid.
Dependencies are inferred from the claim text.