Back to results
US 8,273,786 B2Granted
3-phenoxymethylpyrrolidine compounds
AssigneeTheravance, Inc.
InventorsEric Stangeland, Jane Schmidt, Daisuke Roland Saito, Adam Hughes, Lori Jean Patterson
Life of this patent
Estimating the term…
Abstract
In one aspect, the invention relates to compounds of formula I: where R1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Claims24
A compound of formula I:
- where:
- R1 is selected from —CH2OH, —C1-2alkylene-O—C1-6alkyl, —C1-2alkylene-S—C1-6alkyl, —C1-2alkylene-O-phenyl, —C1-2alkylene-S-phenyl, —C1-2alkylene-O-benzyl, —C1-2alkylene-S-benzyl, tetrahydropyranyl, and tetrahydrofuranyl;
- and
- R2 through R6 are independently selected from hydrogen, halo, —C1-6alkyl, —CF3, —O—C1-6alkyl, —CN, —C(O)—C1-6alkyl, —S—C1-6alkyl, —C3-8cycloalkyl, and —NO2;
- or R4 and R5 are taken together to form —CH═CH—CH═CH—;
- or R5 and R6 are taken together to form —CH—CH═CH—CH—;
- or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.