Inhibitors of UDP-galactopyranose mutase thwart mycobacterial growth
AssigneeWisconsin Alumni Research Foundation
InventorsLaura Lee Kiessling, Emily Carla Dykhuizen, John F. May
Life of this patent
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Abstract
Compounds which inhibit microbial growth or attenuate the virulence of pathogen microorganisms. Compounds of the invention inhibit UDP-galactopyranose mutase (UGM) and have activity as inhibitors of microbial growth of microorganisms which contain this enzyme and particularly those microorganisms in which this enzyme is responsible for the incorporation of galactofuranose residues, particularly for uridine 5′-diphosphate (UDP) galactopyranose mutase. Compounds of the invention inhibit UDP-galactopyranose mutase (UGM) and have activity to attenuate virulence of pathogenic microorganisms, including mycobacteria.
Claims5
A compound having the formula:
- or salts thereof,
- wherein n=0 or 1, RC represents substitution by a halogen at ring position 3 and RB represents substitution by a halogen at ring position 3, substitution by two halogens at ring positions 2 and 4, substitution by two halogens at ring positions 1 and 3, substitution by a nitro group at ring position 2 or substitution by a hydroxyl group at ring position 3.
Dependencies are inferred from the claim text.