Phenoxypyridinylamide compounds

A compound of formula (I):

• wherein:
• R1 is NR7C(O)R8, NR7S(O)2R8 or NR9R10;
• R2 is hydrogen or C1-6 alkyl;
• R3 is hydrogen, halogen, C1-4 alkyl or C1-4 alkoxy;
• R4 is hydrogen, halogen, cyano, hydroxy, C1-4 alkyl, C1-4 alkoxy, CF3, OCF3, C1-4 alkylthio, S(O)(C1-4 alkyl), S(O)2(C1-4 alkyl), CO2H or CO2(C1-4 alkyl);
• R5 is C1-6 alkyl (substituted by NR11R12 or heterocyclyl), C1-6 alkoxy (substituted by NR11R12 or heterocyclyl), C3-6 cycloalkyl (substituted by NR11R12 or heterocyclyl) or heterocyclyl;
• provided that if R5 includes a heterocyclyl then said heterocyclyl comprises one or more ring nitrogen atoms;
• and that if said heterocyclyl is bonded directly via a ring nitrogen either:
• to the alkyl, alkoxy or cycloalkyl of R5, or to the phenyl ring of formula (I) to which R5 is directly bonded, then said heterocyclyl either has at least two ring heteroatoms, or has an NR46R47 substituent;
• R6 is hydrogen, halogen, cyano, hydroxy, SH, C1-4 alkyl, C1-4 alkoxy, CF3, OCF3, C(O)H, C1-6 alkylthio, S(O)(C1-6 alkyl), S(O)2(C1-6 alkyl), CO2H, CO2(C1-6 alkyl), NR13R14, C1-6 alkyl (optionally substituted by halogen, OH, CO2H, NR15R16, NHC(O)O(C1-6 alkyl), OS(O)2(C1-6 alkyl) or heterocyclyl), C1-6 alkoxy (optionally substituted by halogen, OH, CO2H, NR15R16 or heterocyclyl), C3-6 cycloalkyl (optionally substituted halogen, OH, CO2H, NR15R16 or heterocyclyl) or heterocyclyl;
• R7 is hydrogen or C1-6 alkyl (optionally substituted by NR26R27);
• R8 is C1-6 alkyl {optionally substituted by hydroxyl, C1-6 alkoxy, NR21R22, heterocyclyl {optionally substituted by oxo, hydroxy, C1-6 alkyl, CO2(C1-6 alkyl), aryl, heteroaryl, aryl(C1-4 alkyl), heterocyclyl or C(O)(C1-4 alkyl)phenyl}, aryl, heteroaryl, C3-7 cycloalkyl, C3-7 cycloalkyl(C1-4 alkyl), CO2H, CO2(C1-6 alkyl), aryl(C1-4 alkoxy), aryl(C1-4 alkylthio), S(O)2(C1-6 alkyl), NHC(O)heteroaryl or NHC(O)R23}, C1-6 alkoxy, C3-6 cycloalkyl {optionally substituted by hydroxyl, NR24R25 or C1-6 alkyl}, heterocyclyl {optionally substituted by oxo, hydroxy, C1-6 alkyl, amino, aryl, heteroaryl, aryl(C1-4 alkyl), heteroaryl(C1-4 alkyl), heterocyclyl or C(O)(C1-4 alkyl)phenyl}, aryl(C1-4 alkyl) {substituted by amino(C1-4 alkyl)}, aryl or heteroaryl;
• R9 is hydrogen, C1-6 alkyl (optionally substituted by aryl or heteroaryl), aryl or heteroaryl;
• R10 is hydrogen, C1-6 alkyl (optionally substituted by hydroxyl, C1-6 alkoxy, aryl, aryloxy, phenyl(C1-6 alkoxy), heteroaryl, C3-10 cycloalkyl, CO2H, CO2(C1-6 alkyl), NHC(O)O(C1-6 alkyl) or NHC(O)R23), C1-6 alkoxy, C3-6 cycloalkyl (optionally substituted by hydroxy, C1-6 alkyl, phenyl, phenyl(C1-6 alkyl), heteroaryl or heteroaryl(C1-6 alkyl)), heterocyclyl (optionally substituted by C1-6 alkyl, C(O)NH2 or phenyl(C1-6 alkyl)), aryl or heteroaryl;
• R21 and R22 are, independently, hydrogen, C1-6 alkyl or phenyl(C1-4 alkyl);
• R23 is C1-6 alkyl or phenyl;
• the foregoing phenyl, aryl and heteroaryl moieties of R5, R8, R9, R10, R23, R21 and R22 are independently, optionally substituted by:
• halogen, cyano, nitro, CF3, hydroxy, S(O)qR26, OC(O)NR27R28, NR29R30, NR31C(O)R32, NR33C(O)NR34R35, S(O)2NR36R37, NR38S(O)2R39, C(O)NR40R41, C(O)R42, CO2R43, NR44CO2R45, OC(O)(C1-6 alkyl), C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 alkoxy(C1-6)alkyl, amino(C1-4 alkyl), di(C1-6)alkylamino(C1-6)alkyl, C1-6 alkoxy, C1-6 haloalkoxy, hydroxyl (C1-6 alkoxy), heterocyclyl(C1-6 alkoxy), C1-6 alkoxy(C1-6)alkoxy, amino(C1-4 alkoxy), C1-4 alkylamino(C1-4 alkoxy) (itself optionally substituted by phenyl), di(C1-4 alkyl)amino(C1-4 alkoxy), C1-6 alkylthio, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl (itself optionally substituted by C1-4 alkyl or oxo), methylenedioxy, difluoromethylenedioxy, heterocyclyl, heterocyclyl(C1-4 alkyl), phenyl, phenyl(C1-4)alkyl, phenoxy, phenylthio, phenyl(C1-4)alkoxy, heteroaryl, heteroaryl(C1-4)alkyl, heteroaryloxy or heteroaryl(C1-4)alkoxy;
• wherein any of the immediately foregoing phenyl and heteroaryl moieties are optionally substituted with halogen, hydroxy, nitro, S(O)r(C1-4 alkyl), S(O)2NH2, S(O)2NH(C1-4 alkyl), S(O)2N(C1-4 alkyl)2, cyano, C1-4 alkyl, C1-4 alkoxy, C(O)NH2, C(O)NH(C1-4 alkyl), C(O)N(C1-4 alkyl)2, CO2H, CO2(C1-4 alkyl), NHC(O)(C1-4 alkyl), NH(O)2(C1-4 alkyl), C(O)(C1-4 alkyl), CF3 or OCF3;
• q and r are, independently, 0, 1 or 2;
• unless otherwise stated heterocyclyl is optionally substituted by OH, C1-6 alkyl, C3-7 cycloalkyl, NR46R47, (C1-6 alkyl)OH or (C1-6 alkyl)NR48R49, NR50CO2(C1-6 alkyl), CO2(C1-6 alkyl), C(O)(C1-6 alkyl), C(O)heterocyclyl, heteroaryl, (C1-6 alkyl)C(O)NR51R52, (C1-6 alkyl)C(O)NR53R54, (C1-6 alkyl)C(O)heterocyclyl or heterocyclyl;
• R26, R27, R28, R29, R30, R31, R32, R33, R34, R35, R36, R37, R38, R39, R40, R41, R42, R43, R44 and R45, are, independently, C1-6 alkyl {optionally substituted by halogen, hydroxy or C1-6 alkoxy}, CH2(C2-6 alkenyl), phenyl {itself optionally substituted by halogen, hydroxy, nitro, NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2, S(O)2(C1-4 alkyl), S(O)2NH2, S(O)2NH(C1-4 alkyl), S(O)2N(C1-4 alkyl)2, cyano, C1-4 alkyl, C1-4 alkoxy, C(O)NH2, C(O)NH(C1-4 alkyl), C(O)N(C1-4 alkyl)2, CO2H, CO2(C1-4 alkyl), NHC(O)(C1-4 alkyl), NH(O)2(C1-4 alkyl), C(O)(C1-4 alkyl), CF3 or OCF3} or heteroaryl {itself optionally substituted by halogen, hydroxy, nitro, NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2, S(O)2(C1-4 alkyl), S(O)2NH2, S(O)2NH(C1-4 alkyl), S(O)2N(C1-4 alkyl)2, cyano, C1-4 alkyl, C1-4 alkoxy, C(O)NH2, C(O)NH(C1-4 alkyl), C(O)N(C1-4 alkyl)2, CO2H, CO2(C1-4 alkyl), NHC(O)(C1-4 alkyl), NH(O)2(C1-4 alkyl), C(O)(C1-4 alkyl), CF3 or OCF3};
• R27, R28, R29, R30, R31, R32, R33, R34, R35, R36, R37, R38, R40, R41, R42, R43, R44 and R45 can also be hydrogen;
• R12, R14, R15, R25, R47 and R49 are, independently, hydrogen, C1-6 alkyl (optionally substituted by hydroxy, C1-6 alkoxy, C1-6 alkylthio, C3-7 cycloalkyl (optionally substituted by hydroxy) or NR55R56), C3-7 cycloalkyl (optionally substituted by hydroxy(C1-6 alkyl)) or heterocyclyl (optionally substituted by C1-6 alkyl);
• R11, R13, R16, R24, R26, R27, R46, R48, R50, R51, R52, R53, R54 R55 and R56 are, independently, hydrogen or C1-6 alkyl;
• or a N-oxide thereof or a pharmaceutically acceptable salt thereof.