5-pyridinone substituted indazoles

A compound of formula I:

• wherein
• n is 0 or 1;
• R is an optionally substituted pyrrolidin-1-yl;
• R3 and R4 are each independently H or alkyl;
• B is selected from aryl, and cycloalkyl;
• R5, R6, R7 are each independently selected from H, —OH, —O-alkyl, alkyl, halo, —CF3, —CN, and —O-aryl;
• and
• R14 is H or —OH;
• wherein optional substituents are selected from the group consisting of alkyl, halogen, haloalkyl, hydroxy, lower alkoxy, carboxy, carboalkoxy, carboxamido, cyano, carbonyl, nitro, amino, alkylamino, dialkylamino, mercapto, alkylthio, sulfoxide, sulfone, acylamino, amidino, phenyl, benzyl, heteroaryl, phenoxy, benzyloxy, and heteroaryloxy;
• and
• provided that when n is 0, R3 and R4 are H and R is pyrrolidin-1-yl, then
• when B is phenyl which is substituted at the 2-position by methoxy or at the 3-position by methyl, there is at least one additional substituent on the phenyl ring;
• or pharmaceutically acceptable salt thereof.