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US 8,273,769 B2Granted
Phenoxy acetic acid derivatives
AssigneeMerck Serono SA
InventorsStefano Crosignani, Catherine Jorand-Lebrun, Christophe Cleva, Adeline Pretre
Life of this patent
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Abstract
The present invention provides phenoxyacetic acid derivatives of Formula (I) for the treatment of CRTH2 related disorders and disease selected from asthma, atopic dermatitis and inflammatory dermatoses.
Claims12
A compound of Formula (I)
- wherein:
- R1 is H, Hal, A, CN, NO2, OA, CF3, OCF3, Ar or Het,
- Q is Ar, Het,
- n is 0, 1, 2, 3, or 4,
- m is 0, 1 or 2 wherein n+m is not 0,
- Z is phenyl, naphthyl or pyridinyl,
- A is branched or linear alkyl having 1 to 12 C-atoms, wherein one or more, preferably 1 to 7 H-atoms may be replaced by Hal, OR3, CN or N(R3)2 and wherein one or more, preferably 1 to 7 non-adjacent CH2-groups may be replaced by O, NR3 or S and/or by CH═CH— or —C≡C— groups, or denotes cycloalkyl or cycloalkylalkylen having 3 to 7 ring C atoms,
- Hal is F, Cl, Br or I,
- Ar denotes a monocyclic or bicyclic, unsaturated or aromatic carbocyclic ring having 6 to 14 carbon atoms which may be unsubstituted or monosubstituted, disubstituted or trisubstituted or tetrasubstituted by Hal, A, —CH2OA, —CH2SO2A, —CH2OR3, —OR3, CF3, —N(R3)2, NO2, —CN, —NR3COA, —NR3COAr′, —NR3SO2A, —COR3, CON(R3)2, COHet, —SO2N(R3)2, —SOA, —SO2A, Het, or by SO2T, SOT, or Ar′,
- T denotes —(CH2)p—Ar′ or —(CH2)p-Het′,
- p is 0, 1, 2, 3 or 4,
- Ar′ denotes a monocyclic or bicyclic, unsaturated or aromatic carbocyclic ring having 6 to 14 carbon atoms which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by Hal, A, —CH2OA, —CH2OR3, —OR3, —CF3, or —OCF3, Het′ denotes a monocyclic or bicyclic, saturated, unsaturated or aromatic heterocyclic ring, having 1 to 4 N, O and/or S atoms, which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by Hal, A, CH2OA, OR3, CF3, or OCF3,
- Het denotes a monocyclic or bicyclic or tricyclic, saturated, unsaturated or aromatic heterocyclic ring, having 1 to 4 N, O, S atoms, and/or 1 SO2 and/or CO groups and/or NO groups, which may be unsubstituted or monosubstituted, disubstituted or trisubstituted or tetrasubstituted by Hal, A, CH2OA, OR3, CF3, OCF3, N(R3)2, NO2, CN, NR3COA, NR3SO2A, COR3, SO2N(R3)2, SOA, SO2A, or SO2T,
- R3 is H or A,
- Rx, Ry independently denote H, a linear or branched alkyl having 1 to 8 carbon atoms optionally substituted with OH, Hal, CN, or Rx and Ry together form a carbocyclic ring having 3 to 7 carbon atoms, optionally substituted by OH, Hal, or CN;
- and esters, geometrical isomers, optically active enantiomers, racemates or tautomers thereof.
13 more elements
Dependencies are inferred from the claim text.