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US 8,273,758 B2Granted
Substituted tricyclic derivatives
AssigneesSanofi, Mitsubishi Tanabe Pharma Corporation
InventorsAntonio Almario Garcia, Alistair Lochead, Mourad Saady, Philippe Yaiche
Life of this patent
Estimating the term…
Abstract
Compounds of formula (I): wherein: Z, R1, R2, R3, n, and m are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I) and their use in therapeutics.
Claims9
A compound of formula (I):
- wherein:
- Z represents a bond, a carbonyl group, or a methylene group optionally substituted by one or two groups chosen from a C1-6 alkyl group, a hydroxyl group, and a C1-6 alkoxy group;
- R1 represents a 4-pyridine ring or a 4-pyrimidine ring;
- R2 represents a hydrogen atom;
- R3 represents:
- a hydrogen atom;
- a phenyl or a naphthyl group, these groups being optionally substituted by 1 to 4 substituents selected from a C1-6 alkyl group, a halogen atom, a C1-2 perhalogenated alkyl group, a C1-3 halogenated alkyl group, a hydroxyl group, a C1-6 alkoxy group, a C1-2 perhalogenated alkoxy group, a C1-6 alkylsulfonyl group, a nitro, a cyano, an amino, a C1-6 monoalkylamino group, a C2-12 dialkylamino group, an acetoxy group, an aminosulfonyl group, and a heterocyclic group, this heterocyclic group being optionally substituted by a C1-6 alkyl group, a halogen atom, a C1-2 perhalogenated alkyl group, a C1-3 halogenated alkyl group, a hydroxyl group, or a C1-6 alkoxy group;
- or
- a 5, 6 or 5-6 membered heteroaromatic group, this group being optionally substituted by 1 to 4 substituents selected from a C1-6 alkyl group, a halogen atom, a C1-2 perhalogenated alkyl group, a C1-6 halogenated alkyl group, a hydroxyl group, a C1-6 alkoxy group, a C1-6 halogenated alkoxy group, a nitro, a cyano, an amino, a C1-6 monoalkylamino group, a C2-12 dialkylamino group, a S—(C1-6-alkyl) group, a C(O)O(C1-6-alkyl), and a C(O)O(phenyl) group;
- n represents 0 to 3;
- and
- m represents 0 to 1;
- with the proviso that the compound of formula (I) wherein n and m represent 0, Z represents a bond, R2 and R3 represent a hydrogen atom and R1 represents a 4-pyridine ring is not included;
- or an acid addition salt thereof.
11 more elements
A compound of formula (I):
- wherein:
- Z represents a bond, a C1-3 alkyl group, a carbonyl group, or a methylene group optionally substituted by one or two groups chosen from a hydroxyl group;
- R1 represents a 4-pyridine ring or a 4-pyrimidine;
- R2 represents a hydrogen atom;
- R3 represents:
- a phenyl being optionally substituted by 1 to 4 substituents selected from a C1-6 alkyl group, a halogen atom, a C1-2 perhalogenated alkyl group, a C1-6 alkoxy group, a C1-2 perhalogenated alkoxy group, a cyano, a piperidine, or a pyrrolidine being optionally substituted by a C1-6 alkyl group, or
- a 5, 6 or 5-6 membered heteroaromatic group;
- n represents 0 to 3;
- m represents 0 to 1;
- or an acid addition salt thereof.
7 more elements
Dependencies are inferred from the claim text.