4-methylpyridopyrimidinone compounds

A compound of Formula (I)

• or a salt thereof,
• wherein:
• R1 is H or (C1 to C6) alkyl optionally substituted with at least one R5 group;
• A is a 3 to 10 membered cycloalkyl group;
• R2 is (C1 to C6) alkyl substituted with at least one R6 group, (C3 to C10) cycloalkyl, (C2 to C9) cycloheteroalkyl, (C6 to C14) aryl, (C2 to C9) heteroaryl, —NR7aR7b, or —N═CR8aR8b wherein each of the said (C3 to C10) cycloalkyl, (C2 to C9) cycloheteroalkyl, (C6 to C14) aryl, and (C2 to C9) heteroaryl is optionally substituted with at least one R9 group;
• R3 is (C1 to C6) alkyl, (C3 to C10) cycloalkyl, (C2 to C9) cycloheteroalkyl, (C2 to C8) alkenyl, (C2 to C8) alkynyl, halogen, cyano, —(CH2)nC(O)OR10, —(CH2)nC(O)N(R11aR11b), COR12, (C6 to C14) aryl, or (C2 to C9) heteroaryl, wherein said (C1 to C6) alkyl, (C3 to C10) cycloalkyl, (C2 to C9) cycloheteroalkyl, (C2 to C8) alkenyl, (C2 to C8) alkynyl, (C6 to C14) aryl and (C2 to C9) heteroaryl is optionally substituted with at least one R9 group;
• each R4 is independently —OH, halogen, CF3, —NR11aR11b, (C1 to C6) alkyl, (C2 to C6) to alkenyl, (C2 to C6) alkynyl, (C1 to C6) alkoxy, cyano, (C3 to C10) cycloalkyl, (C2 to C9) cycloheteroalkyl, (C6 to C14) aryl, (C2 to C9) heteroaryl, —C(O)R12, —C(O)NR11aR11b, —S(O)mR12, —S(O)mNR11aR11b, —NR11aS(O)mR12, —(CH2)nC(O)OR10, —(CH2)nC(O)N(R11aR11b), —OC(O)R12, —NR11aC(O)R12 or —NR11aC(O)N(R11aR11b) wherein each of the said (C1 to C6) alkyl, (C2 to C6) alkenyl, (C2 to C6) alkynyl, (C1 to C6) alkoxy, (C3 to C10) cycloalkyl, (C2 to C9) cycloheteroalkyl, (C6 to C14) aryl, and (C2 to C9) heteroaryl is optionally substituted with at least one R13 group;
• each R5 is independently —OH, halogen, CF3, —NR11aR11b, (C1 to C6) alkyl, (C1 to C6) alkoxy, cyano, (C3 to C10) cycloalkyl, (C2 to C9) cycloheteroalkyl, (C6 to C14) aryl, (C2 to C9) heteroaryl, —S(O)mR12, —S(O)mNR11aR11b, —C(O)R12 or —C(O)NR11aR11b wherein each of the said (C1 to C6) alkyl, (C1 to C6) alkoxy, (C3 to C10) cycloalkyl, (C2 to C9) cycloheteroalkyl, (C6 to C14) aryl, and (C2 to C9) heteroaryl is optionally substituted with at least one R9 group;
• each R6 is independently —OH, (C2 to C6) alkynyl, cyano, (C3 to C10) cycloalkyl, (C2 to C9) cycloheteroalkyl, (C6 to C14) aryl, (C2 to C9) heteroaryl, —C(O)R12, —C(O)NR11aR11b, —S(O)mR12, —S(O)mNR11aR11b, —NR11aS(O)mR12, —(CH2)nC(O)OR10, —(CH2)nC(O)N(R11aR11b), —OC(O)R12, —NR11aC(O)R12 or —NR11aC(O)N(R11aR11b) wherein each of the said (C2 to C6) alkynyl, (C3 to C10) cycloalkyl, (C2 to C9) cycloheteroalkyl, (C6 to C14) aryl, and (C2 to C9) heteroaryl is optionally substituted with at least one R13 group;
• R7a and R7b are each independently H, (C1 to C6) alkyl, (C2 to C6)alkenyl, (C2 to C6)alkynyl, (C3 to C10) cycloalkyl, or (C6 to C10)aryl, wherein each of the said (C1 to C6) alkyl, (C2 to C6)alkenyl, (C2 to C6)alkynyl, (C3 to C10) cycloalkyl, and (C6 to C10)aryl is optionally substituted with at least one R9 group;
• or R7a and R7b may be taken together with the nitrogen atom to form a 5 to 8 membered cycloheteroalkyl ring, wherein said heterocyclyl ring has 1 to 3 ring heteroatoms selected from the group consisting of N, O, and S and wherein the said 5 to 8 membered cycloheteroalkyl ring is optionally substituted with at least one R9 group;
• R8a and R8b are each independently H, (C1 to C6) alkyl, or (C3 to C10) cycloalkyl wherein each of the said (C1 to C6) alkyl, and (C3 to C10) cycloalkyl, is optionally substituted with at least one R9 group;
• each R9 is independently —OH, halogen, CF3, —NR11aR11b, (C1 to C6) alkyl, (C2 to C6) alkenyl, (C2 to C6) alkynyl, (C1 to C6) alkoxy, cyano, (C3 to C10) cycloalkyl, (C2 to C9) cycloheteroalkyl, (C6 to C14) aryl, (C2 to C9) heteroaryl, —C(O)R12, —C(O)NR11aR11b, —S(O)mR12, —S(O)mNR11aR11b, —NR11aS(O)mR12, —(CH2)nC(O)OR10, —(CH2)nC(O)N(R11aR11b), —OC(O)R12, —NR11aC(O)R12 or —NR11aC(O)N(R11aR11b) wherein each of the said (C1 to C6) alkyl, (C2 to C6) alkenyl, (C2 to C6) alkynyl, (C1 to C6) alkoxy, (C3 to C10) cycloalkyl, (C2 to C9) cycloheteroalkyl, (C6 to C14) aryl, and (C2 to C9) heteroaryl is optionally substituted with at least one R13 group;
• each R10 is independently H, or (C1 to C6) alkyl;
• R11a and R11b are each independently H, (C1 to C6) alkyl, (C2 to C9) cycloheteroalkyl, (C2 to C9) heteroaryl, or (C6 to C12) aryl wherein each of the said (C1 to C6) alkyl, (C2 to C9) cycloheteroalkyl, (C2 to C9) heteroaryl, and (C6 to C12) aryl is optionally substituted with at least one R13 group;
• each R12 is independently (C1 to C6) alkyl, (C3 to C10) cycloalkyl, (C2 to C9) cycloheteroalkyl, (C2 to C9) heteroaryl, or (C6 to C14) aryl wherein each of the said (C1 to C6) alkyl, (C3 to C10) cycloalkyl, (C2 to C9) cycloheteroalkyl, (C2 to C9) heteroaryl, and (C6 to C14) aryl is optionally substituted with at least one R13 group;
• each R13 is independently —OH, halogen, CF3, (C1 to C6) alkyl, (C2 to C6) alkenyl, (C2 to C6) alkynyl, (C1 to C6) alkoxy, cyano, (C3 to C10) cycloalkyl, (C2 to C9) cycloheteroalkyl, (C6 to C14) aryl, (C2 to C9) heteroaryl, amino, C-amido, S-sulfonamido, C-carboxyl, N-amido, or N-carbamyl;
• each m is independently 1 or 2;
• each n is independently 0, 1, 2, 3, or 4;
• and
• each z is independently 0, 1, 2, 3, 4, 5, 6, 7, or 8.