Substituted 1H-pyrazolo[3,4-D]pyrimidine-6-amine compounds

A compound having the formula Ia:

• or a salt thereof, wherein:
• Rn4 is H, or unsubstituted or substituted C1-C6 alkyl;
• Rq1 is H, or unsubstituted or substituted C1-C6 alkyl;
• Rq2 is H, or unsubstituted or substituted C1-C6 alkyl,
• or Rq1 and Rq2, together with the atoms they attach to, form a 5- or 6-membered ring, wherein said ring is optionally unsaturated and optionally contains from 1 to 4 heteroatoms selected form N, O and S, and is optionally substituted;
• Z is —(CH2)m—, —C(O)—, —C(O)C(O)—, —C(O)O—, —C(O)NR1—, —S(O)2—, —S(O)2NR1— or a bond;
• R1 is H, or unsubstituted or substituted C1-C6 alkyl;
• R is unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C1-C6 alkoxy, unsubstituted or substituted C6-C10 aryloxy, unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-member ring and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle, unsubstituted or substituted heterocycle comprising one or two 5- or 6-member ring and 1-4 heteroatoms selected from N, O and S, —C(O)R2, —C(O)OR2, —C(O)NR2R2′, —NR2R2′, —NR2′C(O)R2, or —NR2′C(O)OR2;
• R2 and R2′ are each independently H, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-member ring and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle, or unsubstituted or substituted heterocycle comprising one or two 5- or 6-member ring and 1-4 heteroatoms selected from N, O and S;
• m is 0, 1, 2, 3, or 4;
• and
• w is 1.