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US 8,273,747 B2Granted
Small organic molecule regulators of cell proliferation
AssigneeCuris, Inc.
InventorsShirley Ann Brunton, Oivin M. Guicherit, Lawrence I. Kruse
Life of this patent
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Abstract
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal patched pathway or agonizing smoothened or hedgehog activity.
Claims31
A compound represented by general formula (V):
- wherein, as valence and stability permit,
- Z is a substituted or unsubstituted aryl or heteroaryl ring, provided that Z is not a substituted or unsubstituted pyridine N-oxide ring or a pyridine ring substituted with one or more halogens;
- Ra is methyl;
- R1 is halogen, methoxy, or ethoxy;
- R2 is H;
- Y2 and Y4 are, independently, H or fluoro;
- Y3 is H or fluoro;
- wherein the two nitrogen atoms bonded to the cyclohexane ring depicted in Formula V are in a trans relationship.
5 more elements
Dependencies are inferred from the claim text.