Quinoxaline inhibitors of the hedgehog signalling

A compound of formula I:

• wherein
• A is a carbocycle;
• X is NR4C(O), NR4C(S), NR4C(NH), NR4SO, NR4SO2, NR4C(O)NH, NR4C(S)NH, C(O)NR4, C(S)NR4, C(NH)NR4, or NR4PO(OH) wherein R4 is H or alkyl;
• Y is N, CH or CR3;
• R1 is selected from the group consisting of alkyl, cycloalkyl, aryl or a heterocycle each of which is optionally substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl, haloalkyl or alkoxy;
• and said cycloalkyl, aryl and heterocycle are optionally further substituted with —(CH2)s-(Q)u-(CH2)t—Z wherein Q is C(O), S(O), SO2, C(O)O, OC(O), NR4C(O), NR4C(S), NR4SO, NR4SO2, NR4C(O)NH, NR4C(S)NH, C(O)NR4, or C(S)NR4;
• and Z is hydroxy, amino, halogen, alkylsulfonyl, alkoxy, alkoxycarbonyl, haloalkyl, a carbocycle, a heterocycle or a carbocycle or heterocycle substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl, haloalkyl, hydroxyalkyl, alkoxy or alkoxyalkoxy;
• and s and t are independently 0, 1, 2, 3, 4 or 5 and u is 0 or 1;
• R2 is halogen, hydroxy, alkyl, acyl or alkoxy each optionally substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy;
• R3 is halogen, hydroxy, alkyl, acyl or alkoxy each optionally substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy;
• m is 0, 1, 2, or 3;
• n is 1, 2 or 3;
• or a pharmaceutically acceptable salt thereof.