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US 8,273,742 B2Granted
Disubstituted phthalazine hedgehog pathway antagonists
AssigneeEli Lilly and Company
InventorsPhilip Arthur Hipskind, Bharvin Kumar Patel, Takako Wilson (nee Takakuwa)
Life of this patent
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Abstract
The present invention provides novel 1,4-disubstituted phthalazine hedgehog pathway antagonists useful in the treatment of cancer.
Claims15
A compound of the formula
- wherein:
- R1 is hydrogen or methyl;
- R2 is hydrogen or methyl;
- and
- R3, R4, R5, R6, or R7 are independently hydrogen, fluoro, chloro, cyano, trifluoromethyl, trifluoromethoxy, difluoromethoxy, methylsulfonyl, or trifluoromethylsulfonyl, provided that at least three of R3, R4, R5, R6 and R7 are hydrogen;
- or a pharmaceutically acceptable salt thereof.
3 more elements
A pharmaceutical composition comprising a compound of the formula
- wherein:
- R1 is hydrogen or methyl;
- R2 is hydrogen or methyl;
- and
- R3, R4, R5, R6, or R7 are independently hydrogen, fluoro, chloro, cyano, trifluoromethyl, trifluoromethoxy, difluoromethoxy, methylsulfonyl, or trifluoromethylsulfonyl, provided that at least three of R3, R4, R5, R6 and R7 are hydrogen;
- or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier, diluent or excipient.
3 more elements
Dependencies are inferred from the claim text.